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Understanding Side Effects

TYKERB + capecitabine

Summary of side effects of TYKERB plus capecitabine

 

Serious side effects

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  • Heart problems, including decreased pumping of blood from the heart and an abnormal heartbeat
  • Signs and symptoms of an abnormal heartbeat include:
    • Feeling like your heart is pounding or racing
    • Dizziness
    • Tiredness
    • Feeling light-headed
    • Shortness of breath
  • Your doctor should check your heart function before you start taking TYKERB and during treatment

  • Liver problems can be severe and deaths have happened
  • Signs and symptoms of liver problems include:
    • Itching
    • Yellowing of your skin or the white part of your eyes
    • Dark urine
    • Pain or discomfort in the right upper stomach area
  • Your doctor should do blood tests to check your liver before you start taking TYKERB and during treatment

  • Symptoms of lung problems with TYKERB include:
    • A cough that will not go away
    • Shortness of breath

  • TYKERB may cause severe skin reactions
  • Tell your doctor right away if you develop:
    • Skin rash
    • Red skin
    • Blistering of the lips, eyes, or mouth
    • Peeling skin
    • Fever 
    • Or any combination of these reactions
  • Severe skin reactions can be life threatening, so your doctor may tell you to stop taking TYKERB

  • Diarrhea is common with TYKERB and may sometimes be severe
  • Severe diarrhea can cause loss of body fluid (dehydration) and some deaths have happened
  • Call your doctor right away if you have a change in bowel pattern or if you have severe diarrhea
  • Follow your doctor’s instructions for what to do to help prevent or treat diarrhea

Call your doctor right away if you have any of the signs or symptoms of the serious side effects listed.

Please see the full Prescribing Information for a full listing of the serious side effects.

Common side effects

TYKERB plus capecitabine can cause certain common, less serious side effects. Discuss ways to relieve these side effects with your doctor.

  • Diarrhea (less than severe)
  • Red, painful hands and feet
  • Nausea
  • Rash
  • Vomiting
  • Tiredness or weakness
  • Mouth sores
  • Indigestion
  • Dry skin
  • Back pain
  • Shortness of breath
  • Difficulty sleeping

Tell your doctor if you have any side effect that bothers you or that does not go away.

 

These are not all the possible side effects of TYKERB. For more information, ask your doctor or pharmacist.

 

Call your doctor for medical advice about side effects. You may report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.

 

You may also get side effects from the other medicines taken with TYKERB. Talk to your doctor about possible side effects you may get during treatment.