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Side Effects Management

TYKERB + capecitabine

Diarrhea management

If you get severe diarrhea with TYKERB® (lapatinib) tablets, your doctor may:

  • Give you electrolytes and fluids, either orally or by intravenous infusion
  • Give you antibiotics, especially if your diarrhea continues beyond 24 hours, if you have a fever, or if your white blood cell count is low
  • Interrupt or discontinue your treatment with TYKERB

Diarrhea generally occurs early during treatment with TYKERB.

  • Almost half of patients with diarrhea first experience it within 6 days of starting TYKERB, and it usually lasts 4 to 5 days

Your health care provider may suggest that you have an antidiarrheal medicine such as loperamide on hand to help manage your diarrhea.

  • Talk to your pharmacist to find out what brands contain this medicine
  • Use loperamide only as directed under the supervision of your doctor
  • Talk to your doctor if loperamide does not stop your diarrhea

You may also try these tips to help manage diarrhea that is not severe:

  • Drink at least 8 glasses of clear liquids per day (such as water, broth, or sports drinks)
  • Eat frequent small meals and easily digestible foods such as rice, applesauce, and toast
  • Discontinue any lactose-containing products, alcohol, laxatives, and/or stool softeners
  • Talk to your doctor before making any changes to your diet

You may also get side effects from the other medicines taken with TYKERB. Talk to your doctor about possible side effects you may get during treatment.


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